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Human monoclonal antibodies from West Nile virus survivors show protective potential against WNV and related orthoflaviviruses

No specific prophylaxis or treatment exists for West Nile virus (WNV) or related orthoflavivirus infections. Cervantes Rincón et al. characterize human antibody responses to WNV and identify protective epitopes on the virus envelope protein. A potent mono

Insightsciencehealthimmunologycell.com·Science·3d ago·62 min read

Scientists catalogue newly discovered viruses to identify those with pandemic potential

Newssciencehealth

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theconversation.com12d ago

Systematic mapping of CD4+ T cell epitopes in Nipah and measles viruses reveals cross-reactive immune targets for vaccine development

Insightsciencehealth

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cell.com15d ago

SARS-CoV-2 gene coding capacity enables virus engineering platform for heterologous gene expression

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pnas.org18d ago

Study finds viral adaptation in animal reservoirs is not a necessary precursor for human epidemics and pandemics

Phylogenetic-based selection analysis of viral evolution before and after spillover reveals that viral adaptation in the host reservoir is not a necessary precursor of novel zoonotic virus epidemics and pandemics, including SARS-CoV-2. In contrast, the 19

Insightsciencehealthepidemiologycell.com·Science·18d ago·59 min read

Correspondence: Nirmatrelvir–ritonavir suppresses viral load but may attenuate spike antibody response

We read with interest the Article by David M Lowe and colleagues,1 published in The Lancet Microbe; the authors provide evidence from an open-label randomised trial (the PANORAMIC trial) showing that nirmatrelvir–ritonavir retains virological activity aga

Insightsciencehealthmedical researchthelancet.com·Public Health 🛟·19d ago·3 min read

Intestinal IgA found necessary and sufficient for clearing norovirus in mouse model

Human norovirus is the leading cause of viral gastroenteritis, yet effective vaccines and therapeutics remain elusive. Using murine norovirus as a model, we found that mucosal immunoglobulin A (IgA...

Newssciencehealthimmunology

science.org·Science·23d ago·14 min read

Ten practical guidelines for classifying unknown bacteriophages from genomic data

educationscience

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journals.plos.org24d ago

SARS-CoV-2 directly infects olfactory neurons and causes axonal degeneration via TRPV1 activation, study finds

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cell.com1mo ago

Omicron booster vaccine transiently broadens memory B cell antibody response to SARS-CoV-2 variants

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science.org1mo ago

Omicron booster vaccine transiently broadens memory B cell antibody response to SARS-CoV-2 variants

Newssciencehealth

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science.org1mo ago

New MIST platform reveals individual variability in airborne influenza virus transmission

Newssciencehealth

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cell.com1mo ago

Cryo-EM reveals 2.35 Å structure of Andes hantavirus glycoprotein tetramers on virus-like particles

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cell.com1mo ago

Ecological modeling reveals Crimean-Congo hemorrhagic fever virus circulates through broad networks of ticks and vertebrates

Author summary Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing severe disease in humans across Africa, Asia, and Europe. Understanding where the virus may circulate is crucial for anticipating outbreaks and guiding surveill

Insightsciencehealthepidemiology

journals.plos.org·Science·1mo ago·54 min read