SARS-CoV-2 directly infects olfactory neurons and causes axonal degeneration via TRPV1 activation, study finds
By
Honglin Chen1,2 Send email to [email protected]
The kind of bagel that ruins lesser bagels for you.
Summary
This study demonstrates that SARS-CoV-2 directly infects olfactory sensory neurons through ACE2 upregulation and stimulates basal stem cell proliferation, as shown in human iPSC-derived sensory neurons and validated in golden Syrian hamsters. The research reveals that exposure to live viruses or its S1 spike protein induces TRPV1 channel redistribution from the nucleus to the plasma membrane, resulting in axonal degeneration. These findings provide a mechanistic link between SARS-CoV-2 infection and neurological complications like anosmia (loss of smell), which are among the most frequent and persistent symptoms of COVID-19.
Key quotes
· 3 pulledNeurological complications such as anosmia are among the most frequent and persistent symptoms of COVID-19
SARS-CoV-2 directly infects olfactory sensory neurons through ACE2 upregulation and stimulates basal stem cell proliferation
Exposure to live viruses or its S1 spike protein induces TRPV1 channel redistribution from the nucleus to the plasma membrane, resulting in axonal degeneration
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