Omicron booster vaccine transiently broadens memory B cell antibody response to SARS-CoV-2 variants
This study by Malek et al. evaluated the impact of a SARS-CoV-2 Omicron variant booster vaccine on the memory B cell (MBC) response. Using samples from the COVAIL vaccine trial, the researchers found that individuals who received a booster containing the Omicron variant experienced a transient increase in antibodies capable of binding both ancestral SARS-CoV-2 and the Omicron variant. The research addresses how vaccines may need to be updated to match evolving circulating strains of SARS-CoV-2 as the virus continues to evolve under immune pressure from vaccines and infections.
Key quotes
As SARS-CoV-2 continues to evolve in response to vaccine- and infection-induced immune pressure, vaccines will need to be updated to match currently circulating strains.
Individuals boosted with a vaccine containing the Omicron variant had a transient increase in antibodies that could bind both ancestral SARS-CoV-2 and the Omicron variant.
Evolving endemic viruses such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain major health threats.
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