MYB transcription factor drives enhancer activation and promoter interactions in acute lymphoblastic leukemia
By
Lau, I-Jun, Bloye, Gianna, Smith, Alastair L., Harman, Joe R., Hamley, Joseph C., Sharlandjieva, Vassilena, Denny, Nicholas, Chahrour, Catherine, Li, Hangpeng, Jackson, Nicole E., Vyas, Paresh, Davies, James O. J., Hughes, Jim R., Crump, Nicholas T., Milne, Thomas A.
Summary
This scientific research article investigates the role of MYB transcription factor activity in driving enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia (ALL). The study demonstrates that MYB binding is sufficient to generate enhancers de novo, including the formation of enhancer-promoter contacts, and that loss of MYB in ALL disrupts these critical regulatory interactions. The research provides mechanistic insights into how MYB drives leukemogenesis through chromatin regulation.
Source
bskyMYB transcription factor drives enhancer activation and promoter interactions in acute lymphoblastic leukemiadoi.orgKey quotes
· 3 pulledMYB binding is sufficient to generate enhancers de novo, including the formation of enhancer-promoter contacts.
MYB loss in acute lymphoblastic leukemia disrupts enhancer-promoter interactions.
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.
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