Study reveals CXCL16-driven γδ T cell brain infiltration reduces sociability in autism mouse model
By
Minako Ito
Summary
This study investigates the role of immune cells, specifically γδ T cells, in autism spectrum disorder (ASD) using a mouse model of 15q11-13 duplication (15q dup) syndrome. Researchers found that elevated levels of CXCL16 during development drive increased recruitment of γδ T cells to the brains of 15q dup mice compared to controls. These brain-infiltrating γδ T cells promote ASD-associated behavioral phenotypes, particularly reduced sociability. The study demonstrates that genetic depletion of Vγ6+ γδ T cells or antibody-mediated blockade of interleukin-17A can mitigate these behavioral effects, revealing a mechanistic link between immune cell infiltration and neurodevelopmental behavioral changes.
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Twitter / XStudy reveals CXCL16-driven γδ T cell brain infiltration reduces sociability in autism mouse modelscim.agKey quotes
· 3 pulledLymphocytes are known to shape neurodevelopment and behavior, but their roles in neurodevelopmental disorders such as autism spectrum disorder (ASD) are not well defined.
Using a mouse model of 15q11-13 duplication (15q dup) syndrome, Takayama et al. found that brain-infiltrating γδ T cells promote ASD-associated behavioral phenotypes in mice.
During development, elevated levels of CXCL16 drove increased γδ T cell recruitment to the brains of 15q dup mice relative to control mice.
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