Heat stress exacerbates metabolic dysfunction through skin-hypothalamus axis via KLK14 and astrocyte reprogramming
By
Jia-Jun Zhao3 Send email to [email protected]
Summary
This research article investigates the link between heat stress and metabolic dysfunction. Using mouse models, the study reveals that exposure to heat stress increases susceptibility to diet-induced metabolic disorders. The mechanism involves a skin-hypothalamus axis where elevated skin-derived KLK14 (kallikrein-related peptidase 14) epigenetically reprograms hypothalamic LRRC7+ astrocytes, which in turn suppress neighboring paraventricular nucleus (PVN) OXT neurons. The study also demonstrates that Vitamin A can reduce KLK14 levels and mitigate metabolic impairment in both mice and humans, suggesting a potential therapeutic approach for heat-stress-related metabolic conditions.
Source
bskyHeat stress exacerbates metabolic dysfunction through skin-hypothalamus axis via KLK14 and astrocyte reprogrammingcell.comKey quotes
· 3 pulledWe report that mice exposed to heat stress were more susceptible to metabolic dysfunction upon subsequent exposure to an obesogenic diet.
Heat stress activates a skin-hypothalamus axis via KLK14-dependent epigenetic reprogramming of LRRC7⁺ astrocytes, thereby exacerbating diet-induced metabolic dysfunction.
Vitamin A reduces KLK14 levels and mitigates metabolic impairment in both mice and humans.
You might also wanna read
Cysteine depletion triggers adipose tissue thermogenesis and weight loss
Low Sodium in Blood Triggers Anxiety in Mice by Disrupting Their Brain Chemistry
Skin inflammation as a sentinel marker for neurodegeneration: Chronic skin disorders may signal dementia risk in older adults
This article discusses the emerging link between chronic inflammatory skin conditions and dementia risk in older adults. It highlights that
pubmed.ncbi.nlm.nih.gov·3d ago
Microbial metabolite restores liver health by targeting PPARα and lipid metabolism through the gut-liver axis
This scientific research article reports on the therapeutic potential of a microbial metabolite (10-hydroxy-10-hydr) in alleviating liver in
journals.asm.org·9mo ago
The Interconnection Between Mental Health and Metabolic Health: A Case for Integrated Care
This article from Harvard Medical School explores the deep interconnection between mental health and metabolic health, emphasizing that ment
learn.hms.harvard.edu·4d ago
Study reveals CXCL16-driven γδ T cell brain infiltration reduces sociability in autism mouse model
This study investigates the role of immune cells, specifically γδ T cells, in autism spectrum disorder (ASD) using a mouse model of 15q11-13
scim.ag·2d agoComments
Sign in to join the conversation.
No comments yet. Be the first.