New CRISPR Technique Selectively Destroys Cancer Cells with Common Mutation
By
Andy Murdock
The bagel they save for the regulars. Don't skim, savour.
Summary
Researchers at UC Berkeley, UCSF, and Gladstone Institutes have developed a novel CRISPR-based technique called "RNA-Triggered Chromatin Shredding" that selectively destroys cancer cells carrying a specific mutation found in nearly half of all cancer cases. The approach targets tumor suppressor protein mutations by shredding chromatin in cancer cells while sparing healthy cells, potentially offering a new treatment avenue for previously "undruggable" cancers.
Key quotes
· 3 pulledThe job of a tumor suppressor protein is right in the name: stopping us from getting cancer at the cellular level.
When they're not working properly, the cell is left with limited defenses.
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
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