Study reveals how aging and early life adversity shape DNA methylation across tissues in macaques
By
Noah Snyder-Mackler
Summary
This study examines how aging and early life adversity (ELA) affect DNA methylation (DNAm) across different tissues in rhesus macaques from the semi-free-ranging Cayo Santiago island population. Researchers found that early life adversity often affected the same genetic sites across tissues, even though different types of adversity impacted different sites. In contrast, aging effects were more heterogeneous across tissues. The research helps disentangle the complex interplay between natural aging and stressful early life experiences on epigenetic marks.
Source
Twitter / XStudy reveals how aging and early life adversity shape DNA methylation across tissues in macaquesscience.orgKey quotes
· 3 pulledBoth aging and stressors are known to affect epigenetic marks such as DNA methylation.
Early life adversity often affected the same genetic sites across tissues despite individual sources of adversity affecting different sites, whereas aging effects were more heterogeneous.
Age and early life adversity (ELA) are key determinants of health, but whether they affect similar physiological mechanisms across tissues is unknown.
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