Toward a life-course biology of aging: How early-life conditions shape late-life health and longevity
By
Sara Alam,
4d ago· 42 min readenInsight
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Summary
This article proposes a "life-course biology of aging" framework, arguing that aging is not solely determined by current conditions but is significantly influenced by transient experiences and exposures earlier in life. The authors synthesize evidence from basic aging biology, human epidemiology, and disease-focused studies to show that early-life conditions can have lasting impacts on late-life health and longevity. They call for the aging research field to adopt a whole-life-course perspective to better understand the plasticity of aging outcomes.
Key quotes
· 3 pulledIn the last few years, evidence has emerged from the basic biology of ageing suggesting that ageing can be influenced by transient conditions experienced earlier in life.
The relevance of these finding is supported by decades of research in human epidemiology and disease-focused experimental studies.
We summarise the key findings to propose the ageing field take into consideration the whole life-course of an individual to understand the plasticity of late-life health and longevity.
In the last few years, evidence has emerged from the basic biology of ageing suggesting that ageing can be influenced by transient conditions experienced earlier in life. The relevance of these finding is supported by decades of research in human epidemio
