Midlife plasma GDF15 levels linked to long-term dementia risk, with stronger association for vascular dementia
By
Keenan A. Walker
Summary
This study investigates Growth/differentiation factor–15 (GDF15), a secreted cytokine strongly linked to dementia risk. Using multiple cohorts, researchers found that plasma GDF15 levels measured in midlife are associated with greater dementia risk over 15- to 25-year follow-up periods, with stronger associations for vascular dementia compared to Alzheimer's disease. Two-sample Mendelian randomization analysis supported GDF15's mechanistic role in Alzheimer's disease and related dementias, suggesting GDF15 may be both a biomarker and a driver of dementia risk.
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Twitter / XMidlife plasma GDF15 levels linked to long-term dementia risk, with stronger association for vascular dementiascim.agKey quotes
· 3 pulledPlasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife
Stronger associations observed for vascular, compared to Alzheimer's disease (AD), dementia
Two-sample Mendelian randomization supported plasma GDF15's mechanistic role in AD and related dementias
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