Multi-omics and single-cell CRISPRi screening maps Alzheimer's GWAS variants to TSPAN14 effector gene in microglia

This study presents a variant-to-gene (V2G) mapping effort for Alzheimer disease (AD) that integrates ten brain-relevant genomics datasets—including promoter Capture C, ATAC-seq, and RNA-seq from microglia, neurons, and astrocytes—to fine-map AD GWAS variants and identify effecto