High-dose DHA supplementation reaches brain targets but fails to improve cognition or brain structure in older adults at risk for dementia

Summary

This phase IIa randomized controlled trial investigated high-dose DHA supplementation (2g/day) over 24 months in non-demented older adults (ages 55-80) with low baseline omega-3 intake and at least one dementia risk factor. The study found that high-dose DHA achieved CNS target engagement (increased DHA levels in cerebrospinal fluid) regardless of APOE ε4 carrier status. However, despite this biochemical evidence of target engagement, no significant differences in cognitive performance or brain structure were observed between the DHA and placebo groups over the 24-month period. The researchers conclude that future research should prioritize understanding brain DHA metabolism rather than conducting further supplementation trials.

Source

B

bskyHigh-dose DHA supplementation reaches brain targets but fails to improve cognition or brain structure in older adults at risk for dementiathelancet.com