High-Dose Vitamin D3 During Pregnancy Shows No Cognitive Benefit for Children at Age 10: Secondary Analysis of RCT
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Summary
This post hoc secondary analysis of a randomized clinical trial investigates whether high-dose vitamin D3 supplementation during pregnancy (4400 IU/day) improves offspring cognitive performance at age 10 years compared with standard-dose supplementation (400 IU/day). The study found no statistically significant differences between groups across multiple cognitive domains including intelligence, processing speed, reaction time, and attention. The findings suggest that high-dose prenatal vitamin D3 supplementation does not confer cognitive benefits for children at age 10, despite previous research suggesting potential links between vitamin D levels and neurodevelopment.
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Hacker NewsHigh-Dose Vitamin D3 During Pregnancy Shows No Cognitive Benefit for Children at Age 10: Secondary Analysis of RCTjamanetwork.comKey quotes
· 3 pulledThis post hoc secondary analysis of a randomized clinical trial assesses whether high-dose vitamin D 3 supplementation during pregnancy is associated with improved offspring cognition at age 10 years compared with standard-dose vitamin D 3 supplementation.
Table 1. Overview of Domains, Functions, Tests, and Outcome Metrics in the Neurocognitive Test Battery
Intelligence, Processing speed, Reaction time, Attention
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