Single mild gut infection increases blood-brain barrier permeability and triggers brain inflammation in Parkinson's disease mouse model
By
Sriparna Mukherjee,
Summary
This study investigates the link between gastrointestinal infections and Parkinson's disease (PD) by examining how a single mild infection with Citrobacter rodentium affects blood-brain barrier (BBB) permeability and brain inflammation in Pink1 knockout (KO) and wild-type mice. Using gadolinium-enhanced MRI, the researchers found increased BBB permeability in specific brain regions at 26 days post-infection. While tight-junction and dopamine-related proteins remained unchanged, they observed altered synaptic gene expression, chronic microglial activation, elevated inflammatory markers, and neutrophil infiltration in the brain. The findings suggest that even mild gut infections can increase BBB permeability and potentially enable immune cell infiltration into the brain, which may exacerbate pathways implicated in PD development, particularly in individuals with genetic risk factors like Pink1 mutations.
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Twitter / XSingle mild gut infection increases blood-brain barrier permeability and triggers brain inflammation in Parkinson's disease mouse modeljournals.plos.orgKey quotes
· 3 pulledWe hypothesize that immune system activation is linked to the development of Parkinson's disease (PD).
Previous work revealed that repeated gastrointestinal infections with Citrobacter rodentium causes PD-like symptoms and immune cell invasion in the brain of Pink1 knockout (KO) mice.
Our findings suggest that even mild gastrointestinal infections can increase BBB permeability, potentially enabling immune cell infiltration into the brain and exacerbating pathways implicated in the development of PD, particularly among individuals with genetic risk factors.
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