Study reveals antibiotics disrupt gut microbiome by increasing pancreatic protease activity across IBD and non-IBD patients
By
Lior Lobel3,5,6 Send email to [email protected]
Summary
This study investigates how antibiotics disrupt the gut microbiome and trigger inflammatory bowel disease (IBD)-like proteolytic activity. Using fecal metagenomics and metaproteomics, researchers analyzed patients with pouchitis, ulcerative colitis (UC), and non-IBD controls before and during antibiotic exposure. Results show that antibiotics increase pancreatic protease activity and fecal proteolytic activity while reducing bacterial protease inhibitors across all groups, disrupting the epithelial barrier. The study highlights metaproteomics as a powerful tool for understanding host-microbiome interactions.
Source
bskyStudy reveals antibiotics disrupt gut microbiome by increasing pancreatic protease activity across IBD and non-IBD patientscell.comKey quotes
· 3 pulledAntibiotics (Abx) are essential in medicine but can disrupt gut microbiota, potentially contributing to inflammatory bowel diseases (IBDs).
Proteomic analysis revealed increased pancreatic protease activity and fecal proteolytic activity in all groups, except in patients without IBD before Abx.
Abx-driven disruption of epithelial barrier and highlighting metaproteomics as a powerful approach for dissecting host-microbiome interactions.
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