Advances in Brain-on-a-Chip and BBB-on-a-Chip Models for Neurodegenerative Disease Research
By
Theoharis C. Theoharides
Summary
This article reviews recent progress in brain-on-a-chip and blood-brain barrier (BBB)-on-a-chip microphysiologic platforms for modeling neurodegenerative disorders. It discusses how these platforms use cultured brain cells to study brain disease pathogenesis and treatment, and highlights the role of BBB dysfunction in promoting neuroinflammation and exacerbating disease progression. The article notes that mechanisms of BBB disruption remain poorly understood, presenting a major challenge for developing neurotherapeutics that can cross the BBB.
Source
bskyAdvances in Brain-on-a-Chip and BBB-on-a-Chip Models for Neurodegenerative Disease Researchjournals.sagepub.comKey quotes
· 3 pulledThe blood-brain barrier (BBB) of the neurovascular unit serves as a highly selective molecular transport interface for brain homeostasis.
BBB dysfunction promotes neuroinflammation, exacerbates disease progression, and contributes to neurodegenerative diseases.
The mechanisms of BBB disruption underlying brain disorders remain poorly understood; thus, developing neurotherapeutics that can effectively cross the BBB remains a major challenge.
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