Multi-omics biomarkers in lung fluid predict chronic lung allograft dysfunction after transplantation

Summary

This prospective cohort study investigates multi-omics biomarkers of endothelial dysregulation that precede chronic lung allograft dysfunction (CLAD) in lung transplant recipients. Through analysis of bronchoalveolar lavage fluid samples, the researchers identified molecular features—including proteins, metabolites, and microbial signatures—associated with subsequent lung function decline. The study aims to improve early detection and understanding of CLAD, a major cause of poor long-term outcomes after lung transplantation.

Source

bskyMulti-omics biomarkers in lung fluid predict chronic lung allograft dysfunction after transplantationplos.io