Polarization-sensitive optical coherence tomography enables noninvasive whole-donor-liver viability assessment

Summary

This article presents a research study where Yan et al. applied polarization-sensitive optical coherence tomography (PS-OCT) to noninvasively image entire donor liver surfaces for viability assessment. The technique addresses the critical shortage of viable donor livers by enabling comprehensive whole-organ evaluation, overcoming the limitations of traditional biopsy sampling and histopathology which cannot detect spatial heterogeneity of liver pathology. The researchers developed imaging parameters and machine learning methods to evaluate steatosis, fibrosis, and inflammation, potentially broadening the classification of viable livers for transplantation — especially important as marginal livers from extended criteria donors are increasingly used.

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