Study evaluates procurement biopsy and machine perfusion for kidney transplant outcome prediction using OPTN database
By
Lung-Yi (Felix) Lee1,2 Send email to [email protected]
Master baker tier. Every paragraph earns its place on the tray.
Summary
This retrospective cohort study analyzed data from the Organ Procurement and Transplantation Network database (2014-2022) to evaluate how procurement biopsy findings (glomerulosclerosis levels) and machine perfusion parameters together predict outcomes for kidney transplant recipients. The study included 13,962 adult recipients of solitary kidneys with a Kidney Donor Profile Index of 35% to 85%. Kidneys were categorized by glomerulosclerosis levels (low ≤10%, intermediate 11%-20%, high >20%) and perfusion parameters (good vs. poor). The research aims to determine whether combining these two assessment methods provides better prognostic information for allograft outcomes than either method alone.
Key quotes
· 3 pulledProcurement biopsy and machine perfusion parameters can be utilized to assess donor kidney quality, but information may be incongruent.
Using the Organ Procurement and Transplantation Network database from 2014 to 2022, we performed a retrospective cohort study of all adult recipients of solitary kidneys with a Kidney Donor Profile Index of 35% to 85%, which were biopsied and machine-perfused (N = 13 962).
The biopsies were separated into 'low' (≤10%), 'intermediate' (11%-20%), and 'high' (>20%) glomerulosclerosis (GS).
You might also wanna read
The biological metrics that reveal how our bodies age
The article explores the subtle, measurable biological changes that occur as we age, focusing on objective metrics like kidney filtration ra
empirical.health·7d ago
Satirical Article: SNAP Warns Recipients About Kidney Function Delays
The article is a satirical piece reporting that the Supplemental Nutrition Assistance Program (SNAP) issued a statement warning recipients t
The Onion·6mo agoKidney Recipient Dies After Transplant from Organ Donor Who Had Rabies
Research Suggests Heart Disease, Kidney Disease and Type 2 Diabetes May Be One Condition Treatable with GLP-1 Drugs
The article discusses the emerging medical concept of "CKM syndrome" (cardiometabolic kidney syndrome), which suggests that heart disease, k
scientificamerican.com·5mo ago
AI Chatbots Fill Healthcare Gaps for Chinese Patients Seeking Medical Advice and Companionship
The article explores how patients in China, particularly elderly and chronically ill individuals, are turning to AI chatbots like DeepSeek f
restofworld.org·4mo ago:max_bytes(150000):strip_icc():focal(749x0:751x2)/Mother-with-Lupus-Gets-Kidney-from-Daughter4-050826-5dffe5459cc44e95827817c64ee3ca15.jpg)
Woman with Lupus-Related Kidney Failure Receives Life-Saving Donation from Her Daughter, an EMT
A 70-year-old woman with lupus, Curlean Phillips, experienced kidney failure requiring grueling dialysis treatment. Her daughter, Chanda Cas
People.com·24d ago