DGKζ kinase is essential for CD40-mediated B cell immune synapse formation and antibody production
By
Yolanda R. Carrasco
Summary
This study investigates the role of diacylglycerol kinase ζ (DGKζ) in B lymphocytes during CD40-mediated immune responses. The authors demonstrate that DGKζ is critical for CD40 signaling in mouse B cells, functioning both as a kinase and as an adaptor protein. Loss of DGKζ disrupts synapse-like contacts between B cells and T follicular helper cells, impairs mTORC1 signaling, and prevents the metabolic and transcriptional changes necessary for antibody production. DGKζ-deficient mice showed reduced memory B cell generation. The findings suggest DGKζ inhibition is being explored as a potential therapeutic target.
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Twitter / XDGKζ kinase is essential for CD40-mediated B cell immune synapse formation and antibody productionscim.agKey quotes
· 5 pulledStimulation of the receptor CD40 on B cells by its ligand on T follicular helper cells drives B cell activation, antibody production, and memory cell generation.
Fernández-Barrecheguren et al. showed that the kinase DGKζ mediated CD40 signaling in mouse B cells both as a kinase and as an adaptor.
Loss of DGKζ in CD40-stimulated B cells disrupted their synapse-like contacts with T follicular helper cells and the metabolic and transcriptional changes required for antibody production.
DGKζ-deficient mice exhibited reduced memory B cell generation.
DGKζ inhibition is being explored
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