GPSM1 restricts CD73+CD103+ Treg cells in adipose tissue, critical for promoting obesity-related metabolic deterioration

Study identifies MD-1 as endogenous agonist for orphan receptor GPRC5B, linking macrophages to adipocyte signaling

This article describes research identifying MD-1 as an endogenous agonist for the orphan G protein-coupled receptor GPRC5B. Using a virion-b

Semaglutide Shows Chondroprotective Effects in Osteoarthritis Through Weight Loss-Independent Metabolic Mechanism

This research article demonstrates that semaglutide, a GLP-1 receptor agonist, provides chondroprotective effects in osteoarthritis mouse mo

DGKζ kinase is essential for CD40-mediated B cell immune synapse formation and antibody production

This study investigates the role of diacylglycerol kinase ζ (DGKζ) in B lymphocytes during CD40-mediated immune responses. The authors demon

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

Study reveals how immunotherapy can drive immune evasion in pancreatic cancer through Treg cell activity and MHC-I suppression

This study investigates mechanisms driving immunotherapy resistance in pancreatic ductal adenocarcinoma (PDA). Using murine models, the rese

Study reveals how immunotherapy can drive immune evasion in pancreatic cancer through Treg cell activity and MHC-I suppression

This study investigates mechanisms driving immunotherapy resistance in pancreatic ductal adenocarcinoma (PDA). Using murine models, the rese