Multidimensional aging framework reveals liver-derived coagulation factors as drivers of vascular aging
By
Gang Pei28,30 Send email to [email protected]
Summary
This article presents the mCAS (multicentric Chinese aging standardized cohort) study, which analyzed 2,019 Chinese individuals aged 18–91 to develop a multidimensional framework for quantifying human aging. By integrating clinical, physiological, and molecular-level data, the researchers constructed a three-tiered aging framework including the core capacity clock (CC-clock) for clinical physiological decline and the multimodal clock (MM-clock) for enhanced predictive power. The study reveals highly conserved aging biomarkers and trajectories across multiple centers, and demonstrates that accumulation of liver-derived coagulation factors acts as a mechanistic driver of vascular and systemic aging.
Source
bskyMultidimensional aging framework reveals liver-derived coagulation factors as drivers of vascular agingcell.comKey quotes
· 3 pulledHuman aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges.
Integrating high-dimensional clinical, physiological, and molecular-level data, we constructed a three-tiered aging framework.
The study demonstrates that the accumulation of liver-derived coagulation factors acts as a mechanistic driver of vascular and systemic aging.
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