Extracellular Vesicles as Anti-Aging Therapeutics: Mechanisms, Bioengineering, and Clinical Perspectives
By
Xian Huang
Summary
This comprehensive review article systematically examines the anti-aging potential of extracellular vesicles (EVs), focusing on their multifactorial mechanisms of action across molecular, cellular, and systemic levels. It bridges fundamental EV biology with advanced bioengineering approaches for scalable manufacturing and therapeutic applications. The article covers how EVs can target multiple aging hallmarks including genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion, positioning them as promising next-generation anti-aging therapeutics.
Source
Twitter / XExtracellular Vesicles as Anti-Aging Therapeutics: Mechanisms, Bioengineering, and Clinical Perspectivesonlinelibrary.wiley.comKey quotes
· 3 pulledAging is a complex and systemic biological process involving multiple interconnected pathways and regulatory networks across molecular, cellular, tissue, and organismal levels.
It is characterized by a series of conserved hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence and the senescence-associated secretory phenotype, stem cell exhaustion, deregulated nutrient sensing, altered intercellular communication, and chronic low-grade inflammation.
This review systematically elucidates the multifactorial anti-aging mechanisms of extracellular vesicles (EVs).
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