Moving beyond the debate: Harnessing hippocampal stem cells to combat cognitive aging
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@plosbiology.org
4d ago· 8 min readenInsight
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Summary
This Perspective article argues for moving beyond the debate about whether adult neurogenesis exists in the human hippocampus, and instead focusing on strategies to harness endogenous neural stem cell potential to limit cognitive aging. The authors acknowledge the controversy surrounding human adult neurogenesis but point to mounting evidence supporting its existence. They propose that rather than continuing to debate the phenomenon's existence, researchers should explore how to activate and leverage these stem cells to promote cognitive resilience and potentially slow age-related cognitive decline.
Key quotes
· 3 pulledThis Perspective proposes moving beyond debating the existence of adult neurogenesis, and towards discovering strategies to harness endogenous stem cell potential for resilience against cognitive aging.
The field of human adult neurogenesis has been controversial despite mounting evidence.
Harnessing the stem cell potential in the human hippocampus to limit cognitive aging.
The field of human adult neurogenesis has been controversial despite mounting evidence. This Perspective proposes moving beyond debating the existence of adult neurogenesis, and towards discovering strategies to harness endogenous stem cell potential for