Technology

Art

Milk-derived extracellular vesicles attenuate pre-inflammatory bowel disease via Lactobacillus murinus-mediated TLR2 signaling modulation

Huaxi Yi5 Send email to [email protected]

2d ago· 54 min readenInsight

science health microbiology gastroenterology

Summary

This study identifies milk-derived extracellular vesicles (mEVs) as a nanotherapeutic capable of attenuating pre-inflammatory bowel disease (pre-IBD), a transitional state between IBS and IBD driven by chronic high-fat diet and antibiotic exposure. In mouse models, oral administration of mEVs ameliorated gut microbiota dysbiosis and mucosal inflammation by enriching Lactobacillus murinus and reducing lysophosphatidylcholine (LPC) levels. This microbiota-dependent mechanism reprograms TLR2 signaling toward an anti-inflammatory response, defining a novel microbial strategy for mitigating intestinal inflammation.

Source

bskyMilk-derived extracellular vesicles attenuate pre-inflammatory bowel disease via Lactobacillus murinus-mediated TLR2 signaling modulationcell.com

Key quotes

· 3 pulled

Pre-inflammatory bowel disease (pre-IBD) represents a transitional state between irritable bowel syndrome and IBD, characterized by heightened susceptibility to mucosal inflammation driven by chronic high-fat diet intake and antibiotic exposure.

Here, we identify milk-derived extracellular vesicles (mEVs) as a potent nanotherapeutic capable of attenuating pre-IBD pathology.

This microbiota-dependent mechanism reprograms TLR2 signaling toward an anti-inflammatory response, defining an mEV-modulated microbial strategy for mitigating intestinal inflammation.

Snippet from the RSS feed

Xu et al. show that pre-IBD induced by a combined high-fat diet and antibiotic exposure is alleviated by mEVs through enrichment of L. murinus and reduction of LPC levels. This microbiota-dependent mechanism reprograms TLR2 signaling toward an anti-inflam

You might also wanna read

Extracellular Vesicles as Anti-Aging Therapeutics: Mechanisms, Bioengineering, and Clinical Perspectives

This comprehensive review article systematically examines the anti-aging potential of extracellular vesicles (EVs), focusing on their multif

onlinelibrary.wiley.com·3d ago

Study in mice finds beef-based diet worsens IBD inflammation while pea protein shows protective effects

New research published in Cellular and Molecular Gastroenterology reveals that red meat (beef-based diet) may worsen inflammatory bowel dise

news-medical.net·2d ago

Redirecting

doi.org·17h ago

Microbial metabolite restores liver health by targeting PPARα and lipid metabolism through the gut-liver axis

This scientific research article reports on the therapeutic potential of a microbial metabolite (10-hydroxy-10-hydr) in alleviating liver in

journals.asm.org·10mo ago

Stanford Study: Restoring Gut-Brain Communication Reverses Cognitive Decline in Aging Mice

Stanford Medicine researchers discovered that aging-related changes in gut bacteria composition trigger an inflammatory response that impair

med.stanford.edu·3mo ago

Study Investigates Semen Raphani's Effects on Obesity Through Gut Microbiota and Liver Metabolism Modulation

This article investigates the efficacy of Semen Raphani (RS) in ameliorating high-fat diet (HFD)-induced obesity by modulating gut microbiot

go.acs.org·3d ago

Comments

No comments yet. Be the first.