Redirecting

Drugs that depend on HNE for their mechanism of action? Methamphetamine 😱 I didn't see this one coming. Haven't seen the full-text yet (please send it if you have it), but this study finds that supplementation of Linoleic acid (LA) could worsen meth addiction. Can't think of a country where this might be an issue, can you? ”Supplementation of LA could facilitate, while inhibition of its oxidative metabolism could attenuate the METH-induced CPP [conditioned place preference]. These findings highlight LA metabolism as a potential mechanistic link between gut microbiota dysbiosis and METH reward.” The link to HNE is speculation, more likely it's due to a perturbation of endocannabinoid signalling. But usually I have to use HNE as a proxy for LA consumption. Not here! “Antibiotic-mediated gut microbiota depletion partially attenuates methamphetamine-induced reward and linoleic acid metabolic disturbance” @trikomes #lcl6