LIN28B gene identified as essential for fetal B-cell development and initiation of KMT2A::AFF1 infant leukemia
By
Ling, Rebecca E, Welsh, Alia M, Hamer, Lucy, Jackson, Thomas, Neil, Emily, Elliott, Natalina, Cross, Joe Wilson, Wuppalapati, Arundhati Siddhartha, Smith, Alastair L, Chahrour, Catherine, Sevim, Okan, Palmer, David A, Bozhilov, Yavor, Brown, Elizabeth J, Olender, Leonid, Iskander, Deena, Wang, Guanlin, Rice, Siobhan, O'Byrne, Sorcha, Harman, Joe, Ancliff, Philip, Psaila, Bethan, Wilkinson, Adam C., Morgan, Rhys G, Roberts, Irene AG, Milne, Thomas A, Roy, Anindita
Summary
This scientific research article reports that the fetal-specific gene LIN28B is essential for human fetal B-lymphopoiesis (the development of B cells in the fetus) and plays a critical role in initiating KMT2A::AFF1 infant leukemia, a type of B-cell acute lymphoblastic leukemia (B-ALL) that affects infants. The study identifies LIN28B as a fetal-specific oncogene necessary for both normal fetal B cell development and the initiation of this aggressive infant leukemia.
Source
bskyLIN28B gene identified as essential for fetal B-cell development and initiation of KMT2A::AFF1 infant leukemiadoi.orgKey quotes
· 3 pulledThe fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia
LIN28B, a fetal specific oncogene, is necessary for fetal B lymphopoiesis and KMT2A::AFF1 initiation of infant B ALL
LIN28B stabilizes key fetal
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