Super-resolution spatial transcriptomics reveals ovoid stem cell niche organizing de novo shoot regeneration in tomato
This study uses super-resolution multimodal spatial transcriptomics to profile approximately 1.2 million cells during tomato shoot regeneration from wounding. It identifies an ovoid-structured stem cell niche that organizes plant de novo shoot regeneration in tomato callus. The niche comprises a signaling layer, a plastic compartment, and a quiescent core, in which EPFL8b-mediated signaling contributes to niche organization and regenerative competence. Unlike animal regeneration which relies on pre-existing stem cell reservoirs, plant de novo regeneration depends on callus formation and re-establishment of stem cell niches.
Key quotes
Plant de novo regeneration, unlike regeneration in most animal systems, relies on callus formation and re-establishment of stem cell niches (SCNs) rather than on pre-existing reservoirs.
In this study, we used super-resolution multimodal spatial transcriptomics to profile approximately 1.2 million cells during tomato shoot regeneration from wounding
The niche comprises a signaling layer, a plastic compartment, and a quiescent core, in which EPFL8b-mediated signaling contributes to niche organization and regenerative competence.
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