Age engineering: Creating age-matched tissues for better biomedical models of ageing
By
Pinak Samal1,2,3 Send email to [email protected]
Summary
This article discusses the emerging field of 'age engineering' or 'ageneering' — the methodological approach to engineering the age of tissues in vitro. It explores how creating age-matched tissues (using cells, matrices, and microtissues that reflect specific biological ages) could lead to more representative and predictive models for the ageing population. The forum introduces methodological approaches for artificially or accelerated ageing of tissues and discusses applications in predictive disease modelling, biomarker discovery, and age-specific pharmacotoxicology. The core premise is that current tissue engineering often uses young or neonatal cells, which fail to represent age-related disease mechanisms, and that engineering age into these models is critical for studying conditions prevalent in older populations.
Source
Twitter / XAge engineering: Creating age-matched tissues for better biomedical models of ageingcell.comKey quotes
· 3 pulledTissue engineering aims to restore or replace diseased, damaged, or lost biological tissues in vivo using a combination of cells, biomaterial scaffolds, and/or growth factors, or to generate tissues in vitro for fundamental research or screening applications.
Engineering the age(ing) of tissues in vitro could lead to more representative and predictive models for the ageing population.
This forum introduces methodological approaches for 'age engineering' ('ageneering') and further discusses future applications of age-matched cells, matrices, and microtissues in predictive disease modelling, biomarker discovery, and age-specific pharmacotoxicology.
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