Inferring multicellular interactions in tumors from standard pathology slides

Integrating multi-layer intratumor heterogeneity analysis to advance cancer immunotherapy

This article examines intratumor heterogeneity (ITH) as a multidimensional problem in cancer biology. It discusses how tumors consist of div

Explainable machine learning-guided integrated multiomics analysis reveals macrophage-driven immune suppression in breast cancer

Pan-cancer AI atlas reveals diversity and spatial organization of tertiary lymphoid structures in tumors

Researchers built a pan-cancer atlas of tertiary lymphoid structures (TLSs) in human tumors, developing an AI-based framework to detect and

University of Michigan researchers develop technique to map cell-to-cell communication using spatial transcriptomics

A new University of Michigan study published in Nature Genetics introduces a computational technique that uses spatial transcriptomics to in

Sugar shields help immune cells infiltrate tumors' hostile microenvironment to fight cancer

Cancer is not just a mass of rogue cells but a strategically organized "gated community" with its own tumor microenvironment that can keep t

Refined proximity labeling platform enables tracking of inter-organ protein communication in mice

Researchers have refined a protein-tagging technology called "proximity labeling" and applied it in genetically engineered mice to track cel