Refined proximity labeling platform enables tracking of inter-organ protein communication in mice
By
Rockefeller UniversityJun 22 2026Reviewed
Summary
Researchers have refined a protein-tagging technology called "proximity labeling" and applied it in genetically engineered mice to track cellular protein communication networks. This platform allows scientists to identify which cells are sending specific protein messages between organs, addressing a long-standing challenge in understanding inter-organ communication. The work provides a new way to "listen in" on the molecular conversations that regulate bodily functions like energy storage and immune signaling.
Source
bskyRefined proximity labeling platform enables tracking of inter-organ protein communication in micenews-medical.netKey quotes
· 4 pulledThe body's organs are in constant communication.
Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.
But while scientists have long known these conversations exist, they have struggled to identify exactly which cells are sending which messages.
Now researchers have found a way to listen in.
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