Study finds reactivating Cyclin A2 gene enables adult heart cells to divide, offering potential for self-repair
By
Alisa Kirkin
Summary
A new study published in npj Regenerative Medicine led by Mount Sinai researchers shows that the Cyclin A2 (CCNA2) gene, which is silenced shortly after birth, can be reactivated to make adult heart cells divide again. This discovery could pave the way for gene therapy that enables the human heart to repair itself after heart attacks or failure, potentially eliminating the need for transplants or mechanical pumps.
Source
bskyStudy finds reactivating Cyclin A2 gene enables adult heart cells to divide, offering potential for self-repairinsideprecisionmedicine.comKey quotes
· 3 pulledWe now have a viable therapeutic target in the form of a single gene that can be switched on to regenerate a damaged heart.
The reactivation of Cyclin A2 in adult heart cells caused them to divide and proliferate without losing their structure or function.
This could fundamentally change how we treat heart disease, the leading cause of death worldwide.
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