Single-nucleus RNA atlas reveals transcriptional remodeling of the human heart across the lifespan
By
Jiangping Song
Summary
This study presents a comprehensive single-nucleus RNA sequencing atlas of 442,239 nuclei from 54 nonfailing myocardial tissue samples of 29 individuals, spanning human heart development, adulthood, and aging. The research reveals coordinated yet cell type-specific transcriptional trajectories that converge on progressive loss of gene expression homeostasis and stress responses across all major cardiac cell types throughout the human lifespan.
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Twitter / XSingle-nucleus RNA atlas reveals transcriptional remodeling of the human heart across the lifespanscim.agKey quotes
· 3 pulledThe human heart undergoes continuous transcriptional remodeling from development through aging, yet the cellular and regulatory features governing this process remain incompletely defined.
We generated a single-nucleus RNA sequencing atlas of 442,239 nuclei from 54 nonfailing myocardial tissues of 29 individuals spanning development, adulthood, and aging.
Across all major cell types, we uncovered coordinated yet cell type–specific transcriptional trajectories that converge on progressive loss of gene expression homeostasis, stress responses...
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