TranscriptFormer: Generative AI model maps cellular evolution across 1.5 billion years
By
Theofanis Karaletsos
Summary
Researchers developed TranscriptFormer, a generative AI model that creates a cell atlas spanning 1.5 billion years of evolution by analyzing single-cell transcriptomics data across diverse species. The tool enables comparison of transcriptional programs across the tree of life, from ancient organisms to modern species, revealing conserved and divergent cellular programs. This represents a significant advancement in evolutionary developmental biology and single-cell genomics.
Source
bskyTranscriptFormer: Generative AI model maps cellular evolution across 1.5 billion yearsdoi.orgKey quotes
· 3 pulledSingle-cell transcriptomics is revolutionizing our understanding of cellular diversity, yet comparing transcriptional programs across the tree of life remains challenging.
We developed TranscriptFormer...
This PDF file includes: Other Supplementary Material for this manuscript includes the following: References and Notes
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