Heart's Mechanical Activity Suppresses Tumor Growth, Study Finds

Summary

The heart is one of the organs least likely to develop cancer, a long-standing biological puzzle. A new study published in Science reveals that the mechanical load generated by the heart's beating suppresses tumor cell proliferation through a molecular pathway that alters gene expression. Primary cardiac tumors are exceptionally rare (<1% of autopsies), and even metastases to the heart are often small and asymptomatic. The findings suggest that mechanical forces actively restrain tumor growth, opening potential new therapeutic targets for cancer treatment.

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