Extrachromosomal DNA drives cancer hallmarks through genomic chaos and accelerated evolution
By
Howard Y. Chang20,21,22,24 Send email to [email protected]
Summary
This review article discusses how extrachromosomal DNA (ecDNA) — oncogenic genetic elements that detach from chromosomes and no longer follow Mendelian inheritance — drives genomic chaos and accelerated evolution in cancer. The authors examine the mechanistic basis and impact of ecDNA, showing how it enables many of the Hallmarks of Cancer, a conceptual framework first published 26 years ago that has shaped cancer research from fundamental mechanisms to diagnostics and drug discovery.
Source
bskyExtrachromosomal DNA drives cancer hallmarks through genomic chaos and accelerated evolutioncell.comKey quotes
· 3 pulledThe publication of the Hallmarks of Cancer in Cell 26 years ago was a watershed moment.
By providing an organizing principle and shared language used by laymen and experts alike, the hallmarks concept has shaped cancer research from fundamental mechanisms to diagnostics and drug discovery.
When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensues.
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