Epigenetic control of BMP signaling in dental mesenchyme directs sensory nerve growth during organ development
By
Yang Chai
Summary
This research article investigates how developing organs coordinate sensory innervation during maturation. Using tooth root development as a model system, the study demonstrates that dental mesenchyme actively regulates sensory axon growth through epigenetic control of bone morphogenetic protein (BMP) signaling. Specifically, mesenchymal deletion of Kdm6b disrupts BMP pathway activity and impairs trigeminal axon extension, revealing that cranial neural crest-derived mesenchymal cells play a key role in directing sensory nerve growth through epigenetic mechanisms.
Source
bskyEpigenetic control of BMP signaling in dental mesenchyme directs sensory nerve growth during organ developmentpnas.orgKey quotes
· 4 pulledDeveloping organs must recruit and instruct sensory axon growth and branching as they mature, yet the mechanisms that govern this process remain unclear.
Using tooth root development as a model, where root morphogenesis and sensory innervation initiate and progress simultaneously, we show that dental mesenchyme actively regulates sensory axon growth through epigenetic control of bone morphogenetic protein (BMP) signaling.
Mesenchymal deletion of Kdm6b disrupts BMP pathway activity and impairs trigeminal axon extension.
These results demonstrate that cranial neural crest-derived mesenchymal cells play a key role in directing sensory nerve growth through epigenetic mechanisms.
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