Nicorandil reduces contrast-related kidney injury risk in high-risk PCI patients, study finds
By
Michael Walter
Summary
A study from Dongguan People's Hospital in China found that administering the chest pain drug nicorandil to high-risk PCI patients before and after treatment can significantly reduce their risk of contrast-related kidney injuries. The dose-dependent efficacy is linked to the drug's effects on ATP-sensitive potassium channels and renal microcirculation, with higher doses needed for patients with chronic kidney disease to achieve sufficient renal vasodilation and protective effects.
Source
Twitter / XNicorandil reduces contrast-related kidney injury risk in high-risk PCI patients, study findscardiovascularbusiness.comKey quotes
· 3 pulledThe dose-dependent efficacy observed in our trial is likely rooted in the underlying pathophysiology of renal dysfunction.
In patients with chronic kidney disease, the downregulation of ATP-sensitive potassium channels and impaired renal microcirculation may attenuate the response to conventional doses of nicorandil.
Consequently, a higher dose appears necessary to achieve sufficient renal vasodilation, enhance medullary oxygenation, and exert anti-oxidant and anti-apoptotic effects.
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