Researchers Reverse Kidney Damage in Mice by Targeting Ceramide-Induced Mitochondrial Damage

Serious injury to short-term kidney function, known as acute kidney injury (AKI), can be life-threatening and also raise the likelihood of developing permanent chronic kidney disease.

Researchers at University of Utah Health (U of U Health) have discovered that fatty molecules called ceramides initiate AKI by damaging the mitochondria that supply energy to kidney cells.

By altering ceramide metabolism or using a new drug candidate, the team was able to protect mitochondrial function and completely prevent kidney injury in mice.

AKI can occur after major stressors such as sepsis or heart surgery, and more than half of all intensive care patients experience it.

No approved medications currently exist to treat this condition.