Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology

Shortened TDP-43 isoforms form steric zippers driving aggregation and mislocalization in ALS pathology

This scientific research article investigates shortened TDP-43 (sTDP-43) splice isoforms and their role in neurodegenerative disorders like

Mouse study shows neurons can recover after autophagy suppression is reversed

Researchers developed a mouse model where autophagy (a key cellular waste-cleaning process) can be reversibly switched on and off. Suppressi

Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling

Diesel pollution particles impair lysosomal functions of iPSC-derived microglia

Method to reverse cellular ageing is about to be tested in humans

Alzheimer's Treatment Clears Brain Plaques in Mice Within Hours

Scientists have developed a treatment that repairs the brain's natural gateway system in mice with Alzheimer's-like conditions, allowing amy