Aging impairs antibody responses through defective T follicular helper cell maturation, not B cell dysfunction

Mark M. Davis2,6,8 Send email to [email protected]

2h ago· 51 min readenInsight

science health immunology aging research

Summary

This study investigates why antibody responses decline with age in humans. Using tonsil organoids, single-cell RNA sequencing, and CRISPR perturbations, the researchers mapped age-associated changes in T follicular helper (Tfh) cells. They found that impaired antibody responses with age are primarily driven by defective Tfh cell maturation—specifically the loss of human-specific CXCL13+ Tfh cells—rather than intrinsic B cell dysfunction. Reduced expression of BACH2 and SOX4 were identified as hallmarks of aging-associated humoral immune dysfunction.

Source

bskyAging impairs antibody responses through defective T follicular helper cell maturation, not B cell dysfunctioncell.com

Key quotes

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Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction.

They identify loss of human-specific CXCL13+ T follicular helper cells and reduced BACH2 and SOX4 as hallmarks of aging-associated humoral immune dysfunction.

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear.

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Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of human-specific CXCL13+ T follicular helper cells and reduced

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