Immunological consequences of senescence in physiology and pathology

An integrative approach for studying immunological variation in an aging population – The Milieu Intérieur follow-up study

Study reveals how chronic inflammation drives age-associated CD8+ T cell remodeling

This study by Shchukina et al. investigates how aging and chronic low-grade inflammation remodel the CD8+ T cell compartment. The researcher

Aging impairs antibody responses through defective T follicular helper cell maturation, not B cell dysfunction

This study investigates why antibody responses decline with age in humans. Using tonsil organoids, single-cell RNA sequencing, and CRISPR pe

Method to reverse cellular ageing is about to be tested in humans

Aged circulating CD8+ T cells and their secreted factor granzyme K drive cognitive decline in mice

This study investigates how aged circulating CD8+ T cells contribute to cognitive decline without infiltrating the brain. Using heterochroni

Toward a life-course biology of aging: How early-life conditions shape late-life health and longevity

This article proposes a "life-course biology of aging" framework, arguing that aging is not solely determined by current conditions but is s