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Ten years of TBtools: Lessons in making big data accessible to plant biologists

Plant molecular biology is moving from sequence analysis to omics integration and AI-assisted discovery. Bioinformatics software must improve both computational performance and biologists’ data-exploration efficiency, and future plant bioinformatics workb

Insighttechnologysciencebioinformaticscell.com·Twitter Science (trending)·6d ago·34 min read

D-SPIN: A computational framework for modeling gene regulatory networks from single-cell perturbation data

Insighttechnologyscience

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cell.com6d ago

A Practical Guide to Fine-Tuning Biological Foundation Models with LoRA and NVIDIA BioNeMo

technologyscience

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developer.nvidia.com9d ago

24th Nucleic Acids Research Web Server Issue (2026) features 47 servers; editor previews future concept

technologyscience

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academic.oup.com9d ago

Deep-learning platform GPS enables de novo drug discovery by predicting transcriptomic perturbations from chemical structures

Bulk and single-cell transcriptomics are widely used to characterize diseases and cellular states but remain underexplored for de novo drug discovery. Here, we present a strategy to screen and optimize compounds by matching disease transcriptomic profiles

Insighttechnologysciencebioinformaticscell.com·Science·16d ago·76 min read

Evaluating strategies for integrating phenotypic imaging features with spatial transcriptomics data

Spatial transcriptomics (ST) encompass technologies that measure gene expression in tissue samples without disrupting their organisation, unlike other single-cell techniques. In imaging-based ST spec...

Insighttechnologysciencebioinformatics

onlinelibrary.wiley.com·Science·20d ago·42 min read

Biohub Platform: ESM Protein Models, Atlas, and API for Biomolecular Research

State of the art open protein language models, structure prediction, and interactive tools built on the ESM family.

technologysciencebioinformatics

biohub.ai·Twitter Design (trending)·21d ago·7 min read

Ten practical guidelines for classifying unknown bacteriophages from genomic data

educationscience

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journals.plos.org22d ago

MARRVEL-MCP: A natural-language interface enabling LLMs to use 44 genomic tools for rare disease variant interpretation

Newstechnologyscience

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cell.com23d ago

Microbe Decoder: A web server for predicting functional traits of microbes in microbiome datasets

Newstechnologyscience

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doi.org23d ago

Build a conversational protein research assistant with Amazon Bedrock AgentCore

technologyprogramming

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aws.amazon.com23d ago

ChromoMapperWeb: An interactive web tool for genome assembly evaluation and alignment comparison

Newstechnologyscience

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doi.org23d ago

ChEA-KG: A network-based transcription factor enrichment analysis tool with time-series workflow capabilities

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doi.org23d ago

FLASH-P: AI multi-agent framework builds accurate causal biological networks from literature in under an hour

Mechanistic networks that encode causal regulatory logic can predict the effects of genetic and environmental perturbations but constructing them is a bottleneck in systems biology because the relevant knowledge lies scattered across thousands of resource

Newstechnologyscienceartificial intelligence

sciety.org·Science·23d ago·1 min read

Fitness translocation: a biologically-grounded data augmentation method for improved variant effect prediction

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academic.oup.com24d ago

PrimerWeaver: A free browser-based tool for integrated primer design in molecular biology

Newstechnologyscience

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doi.org25d ago

DeepCYP: A deep learning web server for predicting CYP450 drug metabolism pathways

Newstechnologyscience

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doi.org25d ago

ProteinNetworkSight: A web platform for analyzing multi-feature biological data through interactive network visualization

Insighttechnologyscience

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doi.org27d ago

Wellcome Sanger Institute - Genomics Research Institute in Cambridge1

Ten years of TBtools: Lessons in making big data accessible to plant biologists

D-SPIN: A computational framework for modeling gene regulatory networks from single-cell perturbation data

A Practical Guide to Fine-Tuning Biological Foundation Models with LoRA and NVIDIA BioNeMo

24th Nucleic Acids Research Web Server Issue (2026) features 47 servers; editor previews future concept

Deep-learning platform GPS enables de novo drug discovery by predicting transcriptomic perturbations from chemical structures

Evaluating strategies for integrating phenotypic imaging features with spatial transcriptomics data

Biohub Platform: ESM Protein Models, Atlas, and API for Biomolecular Research

Ten practical guidelines for classifying unknown bacteriophages from genomic data

MARRVEL-MCP: A natural-language interface enabling LLMs to use 44 genomic tools for rare disease variant interpretation

Microbe Decoder: A web server for predicting functional traits of microbes in microbiome datasets

Build a conversational protein research assistant with Amazon Bedrock AgentCore

ChromoMapperWeb: An interactive web tool for genome assembly evaluation and alignment comparison

ChEA-KG: A network-based transcription factor enrichment analysis tool with time-series workflow capabilities

FLASH-P: AI multi-agent framework builds accurate causal biological networks from literature in under an hour

Fitness translocation: a biologically-grounded data augmentation method for improved variant effect prediction

PrimerWeaver: A free browser-based tool for integrated primer design in molecular biology

DeepCYP: A deep learning web server for predicting CYP450 drug metabolism pathways

ProteinNetworkSight: A web platform for analyzing multi-feature biological data through interactive network visualization