Structural and mechanistic insights into the constitutive Themis–Grb2 complex in T cell signalling

AI-guided discovery identifies GPNMB as promising CAR T cell target for multiple cancers

Researchers developed an AI-driven framework for discovering CAR T cell therapy targets by integrating single-cell RNA sequencing data from

Pan-cancer AI atlas reveals diversity and spatial organization of tertiary lymphoid structures in tumors

Researchers built a pan-cancer atlas of tertiary lymphoid structures (TLSs) in human tumors, developing an AI-based framework to detect and

Antibody-ligand motif optimization enables multitarget switchable CAR-T therapy against solid tumors

This article presents a research study on optimizing a multitarget switchable CAR-T (sCAR-T) strategy to overcome antigenic heterogeneity an

Efficient mRNA delivery to resting T cells to reverse HIV latency

Study identifies MD-1 as endogenous agonist for orphan receptor GPRC5B, linking macrophages to adipocyte signaling

This article describes research identifying MD-1 as an endogenous agonist for the orphan G protein-coupled receptor GPRC5B. Using a virion-b

Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells