Manganese perovskite nanocubes convert cold tumors to hot in hepatocellular carcinoma via PANoptosis/STING activation
By
Rui Xie
Summary
This article presents a novel nanosystem for treating hepatocellular carcinoma (HCC) by converting immunologically "cold" tumors into "hot" ones. The researchers developed doping defect–engineered manganese perovskite piezoelectric nanocubes (Mn-BaZrO3, MBZO) integrated with miltirone biomimetic delivery within tumor-derived nanovesicles. This system simultaneously activates PANoptosis (pyroptosis-apoptosis-necroptosis) and the STING pathway to reshape the immune microenvironment, leading to tumor regression in HCC. The approach uses homologous targeting of HCC cells to deliver the nanocubes and trigger an immune response.
Source
Twitter / XManganese perovskite nanocubes convert cold tumors to hot in hepatocellular carcinoma via PANoptosis/STING activationscim.agKey quotes
· 3 pulledHepatocellular carcinoma (HCC) remains a challenge for therapeutic efficacy in converting cold tumors into hot ones.
Doping defect–engineered manganese perovskite piezoelectric nanocubes (Mn-BaZrO3, MBZO) integrated miltirone biomimetic delivery within tumor-derived nanovesicles are proposed for the parallel pyroptosis-apoptosis-necroptosis (PANoptosis) and the stimulator of interferon genes (STING) pathway activation to reshape the immune microenvironment, leading to tumor regression in HCC.
Homologously targeting HCC cells, MBZO nanocubes accumulated and produced exogenous re
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