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Phages redirect vaccine immunity to attack cancer cells in mouse study

By

Tom Bawden

4d ago· 4 min readenNews

Summary

Researchers have demonstrated that bacteriophages (viruses that infect bacteria) can be used to redirect vaccine-induced immunity to attack cancer cells. In a mouse study, vaccinating mice against malaria and then using a harmless phage to direct that immune response toward cancer cells led to tumor eradication in nearly half of the animals. This approach could potentially overcome a key limitation of immunotherapy, which currently fails to benefit many patients.

Source

bskyPhages redirect vaccine immunity to attack cancer cells in mouse studynewscientist.com

Key quotes

· 3 pulled
Bacteria-killing viruses have destroyed cancer cells in mice by redirecting the immunity they built up from vaccinations to attack tumours.
Vaccinating mice against malaria and then using a harmless phage, a virus that infects bacteria, to direct that immune response towards cancer cells resulted in the tumours being eradicated in nearly half of the animals.
Immunotherapy, treatments that use our immune system to fight cancer, has transformed how we treat some forms of the condition, but many people still don't benefit.
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Phages, viruses that infect bacteria, could be genetically manipulated to destroy cancerous cells using the immunity we have acquired from vaccines

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