Mapping the TCR landscape: computational tools empowering translational immunology and therapy design

T cell-myeloid reprogramming overcomes immune resistance in colorectal cancer models

This article presents a scientific study on colorectal cancer (CRC) immunotherapy resistance. It shows that during anti-PD-1 treatment, tumo

Proteomic and phosphoproteomic profiling reveals melanoma cell responses to T cell attack

This study profiles the early proteomic and phosphoproteomic responses of patient-derived melanoma cells when co-cultured with matched autol

Engineered immunotherapy drug eliminates aggressive metastatic cancers in clinical trial

Researchers at Rockefeller University have developed an engineered CD40 agonist antibody that successfully eliminated aggressive metastatic

The immunology of human breast cancer

Explainable machine learning-guided integrated multiomics analysis reveals macrophage-driven immune suppression in breast cancer

Integrating multi-layer intratumor heterogeneity analysis to advance cancer immunotherapy

This article examines intratumor heterogeneity (ITH) as a multidimensional problem in cancer biology. It discusses how tumors consist of div