Harvard Researchers Develop CRISPR Method to Study How Gene Mutations Shape Developing Organs
By
Renate Hellmiss
Summary
Researchers from Harvard's MCB Professor Sharad Ramanathan lab have developed a new CRISPR-based method to study how genetic mutations affect the coordinated movements of thousands of cells that shape developing organs. Published in eLife, this approach addresses a longstanding challenge in developmental biology — understanding how single gene mutations alter organ shape at the tissue level, not just in individual cells.
Source
bskyHarvard Researchers Develop CRISPR Method to Study How Gene Mutations Shape Developing Organsmcb.harvard.eduKey quotes
· 3 pulledUnderstanding how a single genetic mutation can alter the shape of a developing organ has long posed a challenge for developmental biologists.
While researchers can readily study the effects of gene mutations on individual cells, uncovering how those mutations influence the coordinated movements of thousands of cells that sculpt tissues and organs has been much more difficult.
Now, researchers from the lab of MCB Professor Sharad Ramanathan have developed a new approach that makes those questions far easier to investigate.
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