Endothelial Cells as Key Regulators of Skeletal Muscle Health and Regeneration: A Review of the Myovascular Niche
This review article examines the critical role of endothelial cells in skeletal muscle health and regeneration. It highlights how endothelial cells go beyond their traditional function of regulating blood and nutrient flow — they directly interact with muscle stem cells and fibro-adipogenic progenitors to control stem cell quiescence, activation, and muscle tissue remodeling during regeneration and growth. The article presents a comprehensive overview of the "myovascular niche" concept, detailing the complex cellular interplay between muscle stem cells, fibro-adipogenic progenitors, immune cells, and endothelial cells that governs muscle health and disease.
Key quotes
Skeletal muscle health and regeneration are highly orchestrated processes governed by a complex interplay of muscle stem cells, fibro-adipogenic progenitors, immune cells, and endothelial cells.
Endothelial cells play a central role not only by regulating blood and nutrient flow to support metabolic and regenerative needs, but also by directly interacting with muscle stem cells and fibro-adipogenic progenitors to regulate stem cell quiescence or activation.
Endothelial cells... regulate stem cell quiescence or activation, and muscle tissue remodeling during its regeneration and growth.
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