Study identifies postnatal fibroblast population that blocks skin regeneration by driving hyperinnervation
By
Ya-Chieh Hsu1,2,5,7 Send email to [email protected]
Summary
This study reveals that late embryonic full-thickness skin injuries in mammals can regenerate diverse cell types across all lineages (epithelial, mesenchymal, neuronal, and vascular tissues) with proper connectivity. However, this regenerative ability is lost soon after birth, leading to failure in restoring most cell types and hyperinnervation within the wound bed. Single-cell sequencing identified a postnatal wound-specific fibroblast (PWF) population that drives excessive innervation, blocking regeneration. Reducing hyperinnervation at the injury site restores regenerative potential across lineages after postnatal wounding.
Source
bskyStudy identifies postnatal fibroblast population that blocks skin regeneration by driving hyperinnervationcell.comKey quotes
· 4 pulledLate embryonic full-thickness skin injuries heal by regenerating epithelial, mesenchymal, neuronal, and vascular tissues with proper connectivity.
This ability is lost soon after birth, resulting in failure to restore most cell types and hyperinnervation within the wound bed.
Single-cell sequencing identified a postnatal wound-specific fibroblast (PWF) population absent after embryonic wounding.
Reducing hyperinnervation at the injury site restores regenerative potential across lineages after postnatal wounding.
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